‘Real hope’ for cancer cure as personal mRNA vaccine for melanoma trialled (www.theguardian.com)
from MicroWave@lemmy.world to world@lemmy.world on 26 Apr 11:01
https://lemmy.world/post/14716507

Excitement among patients and researchers as custom-built jabs enter phase 3 trial

Doctors have begun trialling in hundreds of patients the world’s first personalised mRNA cancer vaccine for melanoma, as experts hailed its “gamechanging” potential to permanently cure cancer.

Melanoma affects about 132,000 people a year globally and is the biggest skin cancer killer. Currently, surgery is the main treatment although radiotherapy, medicines and chemotherapy are also sometimes used.

Now experts are testing new jabs that are custom-built for each patient and tell their body to hunt down cancer cells to prevent the disease ever coming back.

A phase 2 trial found the vaccines dramatically reduced the risk of the cancer returning in melanoma patients. Now a final, phase 3, trial has been launched and is being led by University College London Hospitals NHS Foundation Trust (UCLH).

Dr Heather Shaw, the national coordinating investigator for the trial, said the jabs had the potential to cure people with melanoma and are being tested in other cancers, including lung, bladder and kidney.

#world

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autotldr@lemmings.world on 26 Apr 11:05 next collapse

This is the best summary I could come up with:


Now experts are testing new jabs that are custom-built for each patient and tell their body to hunt down cancer cells to prevent the disease ever coming back.

A phase 2 trial found the vaccines dramatically reduced the risk of the cancer returning in melanoma patients.

Now a final, phase 3, trial has been launched and is being led by University College London Hospitals NHS Foundation Trust (UCLH).

Dr Heather Shaw, the national coordinating investigator for the trial, said the jabs had the potential to cure people with melanoma and are being tested in other cancers, including lung, bladder and kidney.

It is designed to trigger the immune system so it can fight back against a patient’s specific type of cancer and tumour.

The jab carries coding for up to 34 neoantigens and activates an anti-tumour immune response based on the unique mutations in a patient’s cancer.


The original article contains 604 words, the summary contains 147 words. Saved 76%. I’m a bot and I’m open source!

FlyingSquid@lemmy.world on 26 Apr 11:44 next collapse

But I was told mRNA vaccines change your DNA and anyone who got one would be dead within a few months!

Which reminds me, I need to check to see if I’m due for another COVID booster.

kescusay@lemmy.world on 26 Apr 11:50 next collapse

What, you mean there aren’t literal mountains of corpses everywhere due to the billions of mRNA vaccine doses administered? I’m shocked! Shocked! Well, not that shocked.

These cancer treatments sound really promising. I wonder if they can eventually be used for other cancer types?

anarchrist@lemmy.dbzer0.com on 26 Apr 12:18 next collapse

Should be able to. My dummy understanding is the mrna vaccines are programmable so they just need to find the proteins associated with different cancer cells, program an mrna vaccine to tell your white blood cells to kill cancer and blamo.

kescusay@lemmy.world on 26 Apr 14:16 collapse

Pretty fucking awesome if they can be used that way for pretty much any cancer. Goodbye chemo, hello cancer vaccines!

KneeTitts@lemmy.world on 26 Apr 16:02 collapse

One caveat here, if people get a vaccine for skin cancer, they’ll inevitably spend way way more time in the sun… this will lead to a rise in other forms of cancer like leukemia

billiam0202@lemmy.world on 26 Apr 16:04 collapse

What, you mean there aren’t literal mountains of corpses everywhere due to the billions of mRNA vaccine doses administered?

Of course there are, the globalists are just keeping the lamestream media from reporting it! You just need to look out the window to see them!

…okay, not your window, but trust me, they’re there! Do your own research!

ArcaneGadget@lemmy.world on 26 Apr 11:52 next collapse

Well, the alternative is a good chance of dieing from cancer and/or radiation poisoning. So even if mRNA vaccines did actually mess with DNA, I’d take the chance for a permanent cure.

KneeTitts@lemmy.world on 26 Apr 15:59 collapse

Vaccines represent a prevention, not really a cure. If you prevent something, you never have to cure it.

ArcaneGadget@lemmy.world on 26 Apr 21:01 collapse

Well, kinda. Vaccines are tools for “educating” your immune system. Classical vaccines generally work by providing “dead”/harmless examples of a particular infection, so that your immune system will recognize the real thing and stop it early, so it doesn’t develop to much. The immune system takes a while to get going, so “teaching” it in advance makes a huge difference against aggressive, quick acting infections.

The mRNA vaccines skip most of the “learning phase” and provide the body directly with the template to produce the right antibodies. And this is where the “cure”-part comes in. The whole problem with cancer is that it consists of a variation of your own cells. Which is why the immune system won’t target it. It’s not an infection or foreign. To your immune system it’s just another part of you. mRNA can be used to tell the immune system to attack it anyway, leveraging it against the cancer. But it requires a sample of the cells to be attacked, so as to make the right mRNA for the particular instance of cancer. So it’s not really useable as a preventative thing. At least not yet…

state_electrician@discuss.tchncs.de on 26 Apr 18:46 collapse

I mean, I can guarantee that every single person who gets a mRNA vaccine will die.

Th4tGuyII@kbin.social on 26 Apr 12:11 next collapse

What an odd coincidence - was just watching a news report on this mRNA treatmemt, opened Kbin and this article was right on top of my feed

Rapidcreek@lemmy.world on 26 Apr 12:25 next collapse

I read about this a couple months ago. I remember thinking at the time, “Now that’s a big fucking deal.”

wintermute_oregon@lemm.ee on 26 Apr 14:32 next collapse

They have been working on these for years. It isn’t an mRNA vaccine but Cuba has one for some types of lung cancer.

en.wikipedia.org/wiki/CimaVax-EGF

NegativeInf@lemmy.world on 27 Apr 18:03 collapse

Joe? Is that you?

Fedizen@lemmy.world on 26 Apr 16:06 next collapse

“we’re going to cure cancer” -Joe Biden

This motherfucker.

asteriskeverything@lemmy.world on 27 Apr 01:19 collapse

Now that I think about it though, it’s possible there is much more promise in cancer research behind the scenes that someone like VP and President would be aware of that the public isn’t. It would be really cool if that was the case, and he was intentionally dropping hints because it’s so close? I wanna believe!

kameecoding@lemmy.world on 27 Apr 12:26 next collapse

I am not a vindictive cunt, but people who refused the covid vaccine should be denied any mRNA vaccine in the future too, oh, so now you want the vaccine that it personally affects you? Fuck off

TheFriar@lemm.ee on 27 Apr 14:11 collapse

Believe me, those people are very willing to die on that hill with their hands wrapped firmly around their delusions. We saw that umpteen times during the worst of Covid. They are only going to get more unhinged about new mRNA vaccines.

JimboDHimbo@lemmy.ca on 27 Apr 17:22 next collapse

Will Smith is one step closer to cursing out a mannequin.

Balrog@lemmy.dbzer0.com on 28 Apr 02:44 collapse

Buck Melanoma. Moley Russell’s wart. Not her wart, not her wart. I’m the wart. She’s my tumor.