Anyone know much about the efficacy of the flu part of it? Says it’s more effective than existing ones but is this the revolutionary flu shot that takes us out of the yearly flu vaccine rat race or not that far yet?
Is the “revolutionary flu shot” even feasible at the moment?
From the little I understand about the topic, our hopes of getting rid of the flu are pretty much none until vaccines for the constantly adapting flu virus are very cheap and very quick to develop/deploy.
Until then, the virus will simply adapt to the old vaccines quicker than we can counter it.
I thought there was an effort to target a not-so-easy to change part of the virus. Maybe I’ve been dreaming. Either way the yearly shot, mRNA or otherwise is much more profitable so a one-and-done vaccine won’t appear out of Moderna of Pfizer, that’s for sure.
As if the companies would think long term instead of yearly profit… whoever comes up with a one and done flu vaccine will see an enormous (if short) spike in profits and shareholders will want that spike to sell at the highest price possible and maybe get some dividends along the way.
Tollana1234567@lemmy.today
on 27 Apr 08:03
collapse
the flu basically has one of the highest mutation rate, only HIV is higher. they do it in 3 parts, antigenic shift, genetic drift, and recombination, the last one makes it more dangerous, they can recombine with more than 1 different strain to make a new one, that was the case with h1n1.
rwrwefwef@sh.itjust.works
on 27 Apr 00:09
collapse
Anyone know much about the efficacy of the flu part of it?
A full cohort study would have to be made to attest to that. But guessing from the efficacies of the corona vax, probably not a drastic difference.
is this the revolutionary flu shot that takes us out of the yearly flu vaccine rat race or not that far yet?
Not a chance. As the flu virus mutates every so often, new vaccines will have to be made to adapt to the current epidemiology. It is a circular race.
Flu and corona are both “common cold type” viruses defeating resistance in some way. For coronaviruses that method is stopping the body from building effective resistance by all means possible, so that is why vaccines tend to not work too well.
For the flu it’s the many variations and its tendency to change further and need new antibodies.
So I don’t think a specific flu strain is hard to make a very effective vaccine for, but ofc this doesn’t yet solve the flu problem.
The immense speed at which mRNA vaccines can be developed might improve that in the future, where this here could be one of many steps to get regulatory approval for blanket mrna and actually be permitted to change them at that pace.
In principle mRNA should let you crank you vaccines for new diseases/flu-strains in under a week. If this can fully stop the flu?.. I doubt it. Whatever does solve it will probably make use of this tech though.
FistingEnthusiast@lemmy.world
on 27 Apr 01:47
nextcollapse
The US being behind civilised parts of the world?
I’m shocked… /s
HubertManne@piefed.social
on 27 Apr 02:15
nextcollapse
sigh.
ParlimentOfDoom@piefed.zip
on 27 Apr 02:38
nextcollapse
US has a sewage goblin for its top health official… So that’s not surprising.
Anyone actually surprized by this? The US is currently heading backwards on so many fronts, they are basically a country-sized time machine heading back to the “better” times when gay people were just killed, women had no rights, and black people were slaves.
threaded - newest
Of course.
Goddamnit, Donald.
And there was much rejoicing.
But there was no joy in Mudville.
The US won’t even look at mRNA vaccines anymore.
I don’t need a flu or a COVID vaccine if I die of measles first!
or when the next new NOVEL coranvirus hits, remember the 1st one, it was too lethal and burned itself out.
RFK Jr’s worms isnt.
Anyone know much about the efficacy of the flu part of it? Says it’s more effective than existing ones but is this the revolutionary flu shot that takes us out of the yearly flu vaccine rat race or not that far yet?
Is the “revolutionary flu shot” even feasible at the moment?
From the little I understand about the topic, our hopes of getting rid of the flu are pretty much none until vaccines for the constantly adapting flu virus are very cheap and very quick to develop/deploy. Until then, the virus will simply adapt to the old vaccines quicker than we can counter it.
I thought there was an effort to target a not-so-easy to change part of the virus. Maybe I’ve been dreaming. Either way the yearly shot, mRNA or otherwise is much more profitable so a one-and-done vaccine won’t appear out of Moderna of Pfizer, that’s for sure.
As if the companies would think long term instead of yearly profit… whoever comes up with a one and done flu vaccine will see an enormous (if short) spike in profits and shareholders will want that spike to sell at the highest price possible and maybe get some dividends along the way.
the flu basically has one of the highest mutation rate, only HIV is higher. they do it in 3 parts, antigenic shift, genetic drift, and recombination, the last one makes it more dangerous, they can recombine with more than 1 different strain to make a new one, that was the case with h1n1.
A full cohort study would have to be made to attest to that. But guessing from the efficacies of the corona vax, probably not a drastic difference.
Not a chance. As the flu virus mutates every so often, new vaccines will have to be made to adapt to the current epidemiology. It is a circular race.
Flu and corona are both “common cold type” viruses defeating resistance in some way. For coronaviruses that method is stopping the body from building effective resistance by all means possible, so that is why vaccines tend to not work too well.
For the flu it’s the many variations and its tendency to change further and need new antibodies.
So I don’t think a specific flu strain is hard to make a very effective vaccine for, but ofc this doesn’t yet solve the flu problem.
The immense speed at which mRNA vaccines can be developed might improve that in the future, where this here could be one of many steps to get regulatory approval for blanket mrna and actually be permitted to change them at that pace.
In principle mRNA should let you crank you vaccines for new diseases/flu-strains in under a week. If this can fully stop the flu?.. I doubt it. Whatever does solve it will probably make use of this tech though.
The US being behind civilised parts of the world?
I’m shocked… /s
sigh.
US has a sewage goblin for its top health official… So that’s not surprising.
Anyone actually surprized by this? The US is currently heading backwards on so many fronts, they are basically a country-sized time machine heading back to the “better” times when gay people were just killed, women had no rights, and black people were slaves.
I am so glad they specified “not US”, I almost thought that by “Europe” they actually meant “US”
As an American I appreciate the friendly, and unfriendly, reminders that we not only dropped the ball, we walked away from it.